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2-Methoxymethyl Salvinorin B : ウィキペディア英語版
Salvinorin B methoxymethyl ether

Salvinorin B methoxymethyl ether (2-''O''-methoxymethylsalvinorin B) is a semi-synthetic analogue of the natural product salvinorin A which is used in scientific research. It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. Like the related compound herkinorin, salvinorin B methoxymethyl ether is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant ''Salvia divinorum'', salvinorin A is present in larger quantities.
Salvinorin B methoxymethyl ether has a Ki of 0.60 nM at the κ opioid receptor, and is around 5x more potent than Salvinorin A in animal studies, although it is still only half as potent as its stronger homologue Salvinorin B ethoxymethyl ether.
== See also ==

* Salvinorin B ethoxymethyl ether
* Herkinorin
* RB-64
* Salvinorin A

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